Cordon-Bleu Uses WH2 Domains as Multifunctional Dynamizers of Actin Filament Assembly

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Cordon-Bleu uses WH2 domains as multifunctional dynamizers of actin filament assembly.

Cordon-Bleu is, like Spire, a member of the growing family of WH2 repeat proteins, which emerge as versatile regulators of actin dynamics. They are expressed in morphogenetic and patterning processes and nucleate actin assembly in vitro. Here, we show that Cordon-Bleu works as a dynamizer of actin assembly by combining many properties of profilin with weak filament nucleating and powerful filam...

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ژورنال

عنوان ژورنال: Molecular Cell

سال: 2011

ISSN: 1097-2765

DOI: 10.1016/j.molcel.2011.07.010